Such sad news for Madonna. The singer's dermatologist, Fredric Brandt, was reportedly found dead in his Miami home on April 5.

A spokesperson for the Miami police told Billboard Brandt's death is being investigated as a suicide, t hough the medical examiner has not issued an official cause of death.

According to the Hollywood Reporter, the 65-year-old worked with many celebrity clients, including the "Material Girl" singer and Jane Seymour. Brandt's publicist Jacquie Trachtenberg released a statement to the New York Post.

"He passed away this morning. He was suffering from an illness," Trachtenberg said. "Everyone who knows him is devastated. I worked with him for over 20 years and he was an amazing man, not only was he a brilliant doctor, but he was the kindest human being.”

Lesley Abravanel, a journalist for the Miami Herald, tweeted that depression and reported unflattering comparisons to a character in Unbreakable Kimmy Schmidt could have been factors.

"Sources: Dr Fredric Brandt was 'devastated' over comparisons to the protagonist on Tina Fey’s new Netflix show, 'Unbreakable Kimmy Schmidt,'" she tweeted, writing in a separate tweet, "Dr. Brandt's publicist says he was suffering from an 'illness'. Sources close say that illness was depression."

While the protagonist on the show is Kimmy herself — played by Ellie Kemper — we think the sources are referencing the fictional dermatologist Dr. Grant (whose name is pronounced "Franff"), played by Martin Short.

Shortly after the show's debut in March, the Gloss published a comparison of the fictional character with Brandt, with the writer noting, "Yes, Dr. Grant looks eerily similar to Dr. Brandt, of Dr. Brandt Skincare. And given how similar their names are, too, I think it might be more than a mere coincidence."

You can watch a clip of Dr. Grant's character in Kimmy Schmidt in the video below.