Ready to laugh for a good cause?

Red Nose Day, the comedy-based charity campaign dedicated to raising funds for non-profit organizations that aid youth in poverty, has been organized by Comic Relief and celebrated in the UK for more than 25 years. And now, it’s coming to America for the first time.

On May 21, NBC will air its first ever Red Nose Day fundraising event live in New York City from 8 -11 PM ET, a 3 hour variety show featuring a wide array of actors, artists and personalities — including previously confirmed acts like Sam Smith, Neil Patrick Harris, Coldplay and Jennifer Aniston — for a mixture of comedy, performances and short films.

To raise awareness, Walgreens created selfie stations where store-goers can take silly photos and support Red Nose Day by donating, with part of the proceeds going to the Red Nose Day Fund*. The funds will be distributed by the Comic Relief Fund to organizations including Boys & Girls Clubs of America, Children’s Health Fund, Feeding America, Gavi, The Vaccine Alliance, the Global Fund, LIFT, National Council of La Raza, National Urban League, Oxfam America, Save the Children and United Way.

For more information about the campaign, you can visit Walgreens, as well as the Walgreens Facebook, Twitter and Instagram pages.

*Noses are sold for $1 each, with 50 cents being contributed to the Red Nose Day Fund. No portion of purchase is tax deductible. Red Nose Day Fund’s objective is to lift children and young people out of poverty in the US and overseas. For more information about Red Nose Day Fund, visit RedNoseDay.org.