Rihanna and Adele will perform, Gaga will deliver a tribute to David Bowie and the year's biggest trophies will find their rightful owners.
From 2011 to present day, and through 'Small Bump' and 'I See Fire,' look back at some of the Brit singer's most rousing performances.
'I needed to get knocked down and to build up a thick skin,' she explains.
From Ed Sheeran to Christina Aguilera, some of our favorite celebs helped make a difference by giving back in 2015.
'I'm taking this opportunity of me not having to be anywhere or do anything to travel the world and see everything I missed,' Sheeran shared.
Taylor Swift, Kendrick Lamar and The Weeknd are popping up across categories.
See who else rounded out the Top 5!
We pooled together some of the best (and most bizarre) mashups to come out of the past few years.
'Loved it, you're gonna love it too,' the singer wrote.
Find out who took home a trophy (or six) at the 2015 American Music Awards.